MEK1 Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Widely expressed, with extremely low levels in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of rat Ortholog: 8q24
Cellular Component:  axon; cell cortex; cytoplasm; cytosol; dendrite; dendrite cytoplasm; early endosome; endoplasmic reticulum; focal adhesion; glutamatergic synapse; Golgi apparatus; late endosome; microtubule organizing center; mitochondrion; nucleus; perikaryon; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function:  ATP binding; MAP kinase kinase activity; mitogen-activated protein kinase kinase kinase binding; protein binding; protein C-terminus binding; protein kinase binding; protein N-terminus binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; Ras GTPase binding; scaffold protein binding
Biological Process:  activation of MAPK activity; activation of protein kinase activity; Bergmann glial cell differentiation; cell cycle arrest; cell motility; cell proliferation; cellular senescence; cerebellar cortex formation; epithelial cell proliferation involved in lung morphogenesis; ERK1 and ERK2 cascade; face development; glucose homeostasis; Golgi inheritance; heart development; intracellular signal transduction; keratinocyte differentiation; labyrinthine layer development; lung morphogenesis; MAPK cascade; melanosome transport; mitotic cell cycle; negative regulation of cell proliferation; negative regulation of gene expression; negative regulation of homotypic cell-cell adhesion; negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway; neuron differentiation; neuron projection morphogenesis; peptidyl-threonine phosphorylation; peptidyl-tyrosine phosphorylation; placenta blood vessel development; positive regulation of ATP biosynthetic process; positive regulation of autophagy; positive regulation of axonogenesis; positive regulation of cell differentiation; positive regulation of cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of muscle contraction; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of protein serine/threonine kinase activity; positive regulation of Ras protein signal transduction; positive regulation of transcription elongation from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein heterooligomerization; protein phosphorylation; regulation of axon regeneration; regulation of early endosome to late endosome transport; regulation of ERK1 and ERK2 cascade; regulation of Golgi inheritance; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of stress-activated MAPK cascade; regulation of vascular smooth muscle contraction; response to axon injury; response to glucocorticoid; response to oxidative stress; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade; thymus development; thyroid gland development; trachea formation; triglyceride homeostasis; vesicle transport along microtubule
Reference #:  Q01986 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 1; ERK activator kinase 1; MAP kinase kinase 1; MAP kinase/Erk kinase 1; Map2k1; MAPK/ERK kinase 1; MAPKK 1; MEK 1; Mek1; mitogen activated protein kinase kinase 1; mitogen-activated protein kinase kinase 1; Prkmk1
Gene Symbols: Map2k1
Molecular weight: 43,465 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene