AKR1B10 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose. Belongs to the aldo/keto reductase family. Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.-; EC 1.1.1.21; Lipid Metabolism - linoleic acid; Oxidoreductase
Chromosomal Location of rat Ortholog: 4q22
Cellular Component:  extracellular region; lysosome
Molecular Function:  alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; NADP+ binding; NADP-retinol dehydrogenase activity; NADPH binding; retinal binding; retinal dehydrogenase activity
Biological Process:  cellular detoxification of aldehyde; daunorubicin metabolic process; doxorubicin metabolic process; farnesol catabolic process; polyol metabolic process; retinal metabolic process; retinoid metabolic process; retinol metabolic process
Reference #:  Q6AY99 (UniProtKB)
Alt. Names/Synonyms: Akr1b10; Aldo-keto reductase family 1 member B10; aldo-keto reductase family 1, member B10 (aldose reductase)
Gene Symbols: Akr1b10
Molecular weight: 35,999 Da
Basal Isoelectric point: 8.46  Predict pI for various phosphorylation states
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AKR1B10

Protein Structure Not Found.


Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein