AKR1B10 iso3 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Displays no reductase activity towards glucose. Belongs to the aldo/keto reductase family. Found in many tissues. Highly expressed in small intestine, colon and adrenal gland. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - fructose and mannose; EC 1.1.1.-; EC 1.1.1.21; Lipid Metabolism - linoleic acid; Oxidoreductase
Chromosomal Location of mouse Ortholog: 6|6 B1
Cellular Component:  cytosol; extracellular region; lysosome; mitochondrion
Molecular Function:  alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; estradiol 17-beta-dehydrogenase [NAD(P)] activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; NADP-retinol dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; retinal dehydrogenase activity
Reference #:  G5E895 (UniProtKB)
Alt. Names/Synonyms: 2310005E10Rik; Akr1b10; AKR1B10 iso3; Akr1b16; aldo-keto reductase family 1, member B10; Aldo-keto reductase family 1, member B10 (aldose reductase)
Gene Symbols: Akr1b10
Molecular weight: 35,848 Da
Basal Isoelectric point: 6.8  Predict pI for various phosphorylation states
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AKR1B10 iso3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  BioGPS  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein