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S100B
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Belongs to the S-100 family. Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding |
| Chromosomal Location of human Ortholog: 21q22.3 |
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Cellular Component:
cytoplasm; cytosol; extracellular region; extracellular space; intracellular membrane-bounded organelle; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; ruffle
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Molecular Function:
calcium ion binding; calcium-dependent protein binding; identical protein binding; ion binding; protein binding; protein homodimerization activity; RAGE receptor binding; S100 protein binding; tau protein binding; zinc ion binding
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Biological Process:
axonogenesis; central nervous system development; learning or memory; memory; positive regulation of cell population proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of neuronal synaptic plasticity
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Reference #:
P04271
(UniProtKB)
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Alt. Names/Synonyms: NEF; Protein S100-B; S-100 calcium-binding protein, beta chain; S-100 protein beta chain; S-100 protein subunit beta; S100; S100 beta; S100 calcium binding protein B; S100 calcium binding protein, beta (neural); S100 calcium-binding protein B; S100 calcium-binding protein, beta (neural); S100-B; S100B; S100beta
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Gene Symbols: S100B
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Molecular weight:
10,713 Da
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Basal Isoelectric point:
4.57
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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