Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: EC 126.96.36.199; Protein phosphatase, Ser/Thr (non-receptor)
Molecular Function: ADP binding; ATP binding; G-protein alpha-subunit binding; Hsp90 protein binding; identical protein binding; lipid binding; metal ion binding; microtubule binding; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; RNA binding; tau protein binding
Biological Process: cellular response to cadmium ion; cellular response to hydrogen peroxide; DNA repair; histone dephosphorylation; MAPK cascade; mitotic cell cycle; negative regulation of neuron death; negative regulation of protein phosphorylation; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of glucocorticoid receptor signaling pathway; protein dephosphorylation; protein heterooligomerization; response to arachidonic acid; response to lead ion; response to morphine; transcription, DNA-templated