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PPP4C
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 16p11.2 |
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Cellular Component:
chromatin; cytoplasm; cytosol; microtubule organizing center; nucleoplasm; nucleus; plasma membrane; protein phosphatase 4 complex
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Molecular Function:
metal ion binding; myosin phosphatase activity; NF-kappaB-inducing kinase activity; protein binding; protein serine/threonine phosphatase activity
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Biological Process:
double-strand break repair via homologous recombination; NIK/NF-kappaB signaling; regulation of double-strand break repair; regulation of double-strand break repair via homologous recombination
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Reference #:
P60510
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; PP-X; PP4; PP4C; PPH3; PPP4; PPP4C; PPX; protein phosphatase 4 (formerly X), catalytic subunit; protein phosphatase 4 catalytic subunit; protein phosphatase 4, catalytic subunit; Protein phosphatase X; protein phosphatase X, catalytic subunit; Serine/threonine-protein phosphatase 4 catalytic subunit
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Gene Symbols: PPP4C
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Molecular weight:
35,080 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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