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PPM1B
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Belongs to the PP2C family. Highly expressed in heart and skeletal muscle. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 17 E4|17 55.13 cM |
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Cellular Component:
cytoplasm; cytosol; membrane; nucleolus; nucleus
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Molecular Function:
cation binding; hydrolase activity; magnesium ion binding; manganese ion binding; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity
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Biological Process:
N-terminal protein myristoylation; negative regulation of defense response to virus; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interferon-beta production; negative regulation of NIK/NF-kappaB signaling; peptidyl-threonine dephosphorylation; positive regulation of canonical Wnt signaling pathway; protein dephosphorylation
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Reference #:
P36993
(UniProtKB)
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Alt. Names/Synonyms: MGC106489; PP2; PP2C-beta; Pp2c2; PP2CB; Ppm1b; Pppm1b; Protein phosphatase 1B; protein phosphatase 1B, magnesium dependent, beta isoform; Protein phosphatase 2C isoform beta
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Gene Symbols: Ppm1b
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Molecular weight:
42,795 Da
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Basal Isoelectric point:
5.04
Predict pI for various phosphorylation states
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