PPP2CB PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Belongs to the PPP phosphatase family. PP-1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 8p12
Cellular Component:  chromosome, centromeric region; cytosol; nucleus; protein phosphatase type 2A complex; spindle pole
Molecular Function:  metal ion binding; protein binding; protein C-terminus binding; protein serine/threonine phosphatase activity; tau protein binding
Biological Process:  apoptotic mitochondrial changes; negative regulation of Ras protein signal transduction; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of microtubule binding; proteasome-mediated ubiquitin-dependent protein catabolic process; protein dephosphorylation; regulation of gene expression; response to endoplasmic reticulum stress; response to hydrogen peroxide; response to lead ion
Reference #:  P62714 (UniProtKB)
Alt. Names/Synonyms: PP2A-beta; PP2AB; PP2Abeta; PP2CB; PPP2CB; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2 catalytic subunit beta; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146
Gene Symbols: PPP2CB
Molecular weight: 35,575 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  PI3K/Akt Signaling  |  TGF-ß Signaling  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB