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PPP3CC
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. Testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: 14|14 D2 |
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Cellular Component:
calcineurin complex; cytoplasm; cytosol; glutamatergic synapse; mitochondrion; presynapse; presynaptic cytosol; protein serine/threonine phosphatase complex; sperm flagellum; sperm midpiece; sperm mitochondrial sheath
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Molecular Function:
calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein phosphatase activity; hydrolase activity; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity
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Biological Process:
calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; negative regulation of calcium ion import across plasma membrane; negative regulation of voltage-gated calcium channel activity; penetration of zona pellucida; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium ion import across plasma membrane; positive regulation of synaptic vesicle endocytosis; positive regulation of voltage-gated calcium channel activity; protein dephosphorylation; regulation of synaptic vesicle endocytosis
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Reference #:
P48455
(UniProtKB)
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Alt. Names/Synonyms: Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform; Calnc; CAM-PRP catalytic subunit; PP2BA gamma; PP2BC; Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
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Gene Symbols: Ppp3cc
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Molecular weight:
58,699 Da
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Basal Isoelectric point:
6.84
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Mitochondrial Control of Apoptosis
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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