PPP3CC Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. Testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component:  cytoplasm; cytosol; glutamatergic synapse; mitochondrion; presynaptic cytosol
Molecular Function:  calmodulin-dependent protein phosphatase activity; metal ion binding; protein binding
Biological Process:  brain development; calcineurin-NFAT signaling cascade; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; positive regulation of synaptic vesicle endocytosis; protein dephosphorylation
Reference #:  P48454 (UniProtKB)
Alt. Names/Synonyms: Calcineurin, testis-specific catalytic subunit; Calmodulin-dependent calcineurin A subunit gamma isoform; CALNA3; CAM-PRP catalytic subunit; CNA3; PP2BC; PP2Bgamma; PPP3CC; protein phosphatase 2B, catalytic subunit, gamma isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform; protein phosphatase 3, catalytic subunit, gamma isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
Gene Symbols: PPP3CC
Molecular weight: 58,129 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB