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PPP3CB
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of Human Ortholog: 15p16 |
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Cellular Component:
calcineurin complex; cytoplasm; cytosol; glutamatergic synapse; plasma membrane; protein-containing complex; synapse; T-tubule; Z disc
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Molecular Function:
calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein phosphatase activity; drug binding; enzyme binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein phosphatase 2B binding; protein serine/threonine phosphatase activity
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Biological Process:
brain development; calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; calcium ion regulated exocytosis; cellular response to drug; heart development; locomotion involved in locomotory behavior; lymphangiogenesis; muscle cell cellular homeostasis; negative regulation of T cell mediated cytotoxicity; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; protein phosphorylation; regulation of gene expression; regulation of insulin secretion; regulation of synaptic vesicle endocytosis; response to amphetamine; response to cytokine; social behavior; T cell differentiation; T cell homeostasis
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Reference #:
P20651
(UniProtKB)
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Alt. Names/Synonyms: Calcineurin subunit A beta; Calmodulin-dependent calcineurin A subunit beta isoform; Calna2; CAM-PRP catalytic subunit; PP2BB; Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
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Gene Symbols: Ppp3cb
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Molecular weight:
59,113 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Mitochondrial Control of Apoptosis
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T Cell Receptor Signaling
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