PPP3CB Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 15p16
Cellular Component:  calcineurin complex; cytoplasm; cytosol; glutamatergic synapse; plasma membrane; protein-containing complex; synapse; T-tubule; Z disc
Molecular Function:  calcium ion binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein phosphatase activity; enzyme binding; myosin phosphatase activity; protein binding; protein dimerization activity; protein phosphatase 2B binding; protein serine/threonine phosphatase activity; protein-containing complex binding
Biological Process:  brain development; calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; calcium-ion regulated exocytosis; heart development; locomotion involved in locomotory behavior; lymphangiogenesis; muscle cell cellular homeostasis; negative regulation of signaling; negative regulation of T cell mediated cytotoxicity; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; protein phosphorylation; regulation of gene expression; regulation of insulin secretion; regulation of synaptic vesicle endocytosis; regulation of transport; response to amphetamine; response to cytokine; skeletal muscle fiber development; T cell differentiation; T cell homeostasis; T cell mediated cytotoxicity
Reference #:  P20651 (UniProtKB)
Alt. Names/Synonyms: Calcineurin subunit A beta; Calmodulin-dependent calcineurin A subunit beta isoform; Calna2; CAM-PRP catalytic subunit; PP2BB; Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Gene Symbols: Ppp3cb
Molecular weight: 59,113 Da
Basal Isoelectric point: 5.6  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene