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PPP3CB
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. Belongs to the PPP phosphatase family. PP-2B subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 10q22.2 |
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Cellular Component:
calcineurin complex; cytoplasm; cytosol; glutamatergic synapse; nucleoplasm; plasma membrane; protein serine/threonine phosphatase complex; T-tubule; Z disc
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Molecular Function:
calcium ion binding; calmodulin binding; calmodulin-dependent protein phosphatase activity; enzyme binding; myosin phosphatase activity; protein binding; protein dimerization activity; protein phosphatase 2B binding; protein serine/threonine phosphatase activity
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Biological Process:
axon extension; calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; calcium-ion regulated exocytosis; dephosphorylation; heart development; learning; locomotion involved in locomotory behavior; lymphangiogenesis; memory; negative regulation of calcium ion import across plasma membrane; negative regulation of signaling; negative regulation of T cell mediated cytotoxicity; negative regulation of voltage-gated calcium channel activity; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium ion import across plasma membrane; positive regulation of DNA-templated transcription; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of lysosome organization; positive regulation of protein localization to nucleus; positive regulation of transcription by RNA polymerase II; positive regulation of voltage-gated calcium channel activity; protein dephosphorylation; protein phosphorylation; regulation of insulin secretion; regulation of synaptic plasticity; regulation of synaptic vesicle endocytosis; response to cytokine; signal transduction; skeletal muscle fiber development; T cell activation; T cell differentiation; T cell homeostasis; T cell mediated cytotoxicity; T cell proliferation
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Reference #:
P16298
(UniProtKB)
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Alt. Names/Synonyms: calcineurin A beta; calcineurin A2; Calmodulin-dependent calcineurin A subunit beta isoform; CALNA2; CALNB; CAM-PRP catalytic subunit; CNA beta; CNA2; PP2BB; PP2Bbeta; PPP3CB; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; protein phosphatase 3 catalytic subunit beta; protein phosphatase 3, catalytic subunit, beta isozyme; protein phosphatase from PCR fragment H32; Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
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Gene Symbols: PPP3CB
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Molecular weight:
59,024 Da
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Basal Isoelectric point:
5.6
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Mitochondrial Control of Apoptosis
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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