PPP3CA Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Belongs to the PPP phosphatase family. PP-2B subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 4q24
Cellular Component:  calcineurin complex; cytoplasm; cytosol; dendritic spine; glutamatergic synapse; mitochondrion; nucleoplasm; sarcolemma; Schaffer collateral - CA1 synapse; slit diaphragm; Z disc
Molecular Function:  calcium ion binding; calmodulin binding; calmodulin-dependent protein phosphatase activity; cyclosporin A binding; drug binding; enzyme binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein serine/threonine phosphatase activity
Biological Process:  aging; brain development; calcineurin-NFAT signaling cascade; calcium ion transport; cardiac muscle hypertrophy in response to stress; cellular response to drug; cellular response to glucose stimulus; dephosphorylation; excitatory postsynaptic potential; Fc-epsilon receptor signaling pathway; G1/S transition of mitotic cell cycle; multicellular organismal response to stress; negative regulation of chromatin binding; negative regulation of dendrite morphogenesis; negative regulation of insulin secretion; negative regulation of production of miRNAs involved in gene silencing by miRNA; peptidyl-serine dephosphorylation; positive regulation of cardiac muscle hypertrophy in response to stress; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of connective tissue replacement; positive regulation of DNA-binding transcription factor activity; positive regulation of endocytosis; positive regulation of transcription by RNA polymerase II; postsynaptic modulation of chemical synaptic transmission; protein dephosphorylation; protein import into nucleus; response to amphetamine; response to calcium ion; skeletal muscle fiber development; skeletal muscle tissue regeneration; T cell activation; transition between fast and slow fiber; Wnt signaling pathway, calcium modulating pathway
Disease: Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development; Epileptic Encephalopathy, Infantile Or Early Childhood
Reference #:  Q08209 (UniProtKB)
Alt. Names/Synonyms: ACCIID; calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA; CNA1; IECEE; IECEE1; PP2BA; PPP2B; PPP3CA; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Gene Symbols: PPP3CA
Molecular weight: 58,688 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Mitochondrial Control of Apoptosis  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein