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PPP3CA
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Many of the substrates contain a PxIxIT motif and/or a LxVP motif. In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation. In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion. Dephosphorylates heat shock protein HSPB1. Dephosphorylates and activates transcription factor NFATC1. In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32. May dephosphorylate CRTC2 at 'Ser-171' resulting in CRTC2 dissociation from 14-3-3 proteins. Belongs to the PPP phosphatase family. PP-2B subfamily. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Protein phosphatase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 4q24 |
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Cellular Component:
calcineurin complex; cytoplasm; cytoplasmic side of plasma membrane; cytosol; dendritic spine; extrinsic component of plasma membrane; glutamatergic synapse; mitochondrion; nucleoplasm; plasma membrane; protein serine/threonine phosphatase complex; sarcolemma; Schaffer collateral - CA1 synapse; slit diaphragm; Z disc
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Molecular Function:
ATPase binding; calcium ion binding; calmodulin binding; calmodulin-dependent protein phosphatase activity; cyclosporin A binding; enzyme binding; molecular function activator activity; myosin phosphatase activity; protein binding; protein dimerization activity; protein serine/threonine phosphatase activity; protein-containing complex binding
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Biological Process:
calcineurin-mediated signaling; calcineurin-NFAT signaling cascade; calcium ion transport; cardiac muscle hypertrophy in response to stress; cellular response to glucose stimulus; dendrite morphogenesis; dephosphorylation; epidermis development; excitatory postsynaptic potential; G1/S transition of mitotic cell cycle; keratinocyte differentiation; modulation of chemical synaptic transmission; multicellular organismal response to stress; negative regulation of calcium ion import across plasma membrane; negative regulation of chromatin binding; negative regulation of dendrite morphogenesis; negative regulation of gene expression; negative regulation of insulin secretion; negative regulation of signaling; negative regulation of voltage-gated calcium channel activity; peptidyl-serine dephosphorylation; positive regulation of activated T cell proliferation; positive regulation of calcineurin-NFAT signaling cascade; positive regulation of calcium ion import across plasma membrane; positive regulation of cardiac muscle hypertrophy in response to stress; positive regulation of cell adhesion; positive regulation of cell migration; positive regulation of connective tissue replacement; positive regulation of DNA-binding transcription factor activity; positive regulation of endocytosis; positive regulation of gene expression; positive regulation of glomerulus development; positive regulation of osteoblast differentiation; positive regulation of osteoclast differentiation; positive regulation of saliva secretion; positive regulation of transcription by RNA polymerase II; positive regulation of voltage-gated calcium channel activity; postsynaptic modulation of chemical synaptic transmission; protein dephosphorylation; protein import into nucleus; regulation of cell proliferation involved in kidney morphogenesis; renal filtration; response to amphetamine; response to calcium ion; skeletal muscle fiber development; skeletal muscle tissue regeneration; T cell activation; transition between fast and slow fiber; wound healing
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Disease: Arthrogryposis, Cleft Palate, Craniosynostosis, And Impaired Intellectual Development; Epileptic Encephalopathy, Infantile Or Early Childhood
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Reference #:
Q08209
(UniProtKB)
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Alt. Names/Synonyms: ACCIID; calcineurin A alpha; Calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA; CNA1; IECEE; IECEE1; PP2BA; PPP2B; PPP3CA; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; Protein phosphatase 3 catalytic subunit alpha; protein phosphatase 3 catalytic subunit alpha isozyme; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
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Gene Symbols: PPP3CA
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Molecular weight:
58,688 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Mitochondrial Control of Apoptosis
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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