PPM1F Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. Belongs to the PP2C family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of rat Ortholog: 11q23
Cellular Component:  cytosol; nucleus; perinuclear region of cytoplasm; protein-containing complex
Molecular Function:  calmodulin-dependent protein phosphatase activity; metal ion binding; myosin phosphatase activity; phosphoprotein phosphatase activity; protein serine/threonine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  cellular response to xenobiotic stimulus; intrinsic apoptotic signaling pathway; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of DNA-templated transcription; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein kinase activity; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of protein transport; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of chemotaxis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell migration; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of growth; positive regulation of stress fiber assembly; protein dephosphorylation; regulation of protein localization
Reference #:  Q9WVR7 (UniProtKB)
Alt. Names/Synonyms: Ca(2+)/calmodulin-dependent protein kinase phosphatase; calcium/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CaMKPase; Partner of PIX 2; Popx2; Ppm1f; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing)
Gene Symbols: Ppm1f
Molecular weight: 49,165 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Select Structure to View Below

PPM1F

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene