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ANO3
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide. Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity. Does not exhibit calcium-activated chloride channel (CaCC) activity. Belongs to the anoctamin family. Highly expressed in the forebrain striatum. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel |
| Chromosomal Location of human Ortholog: 11p14.3-p14.2 |
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Cellular Component:
plasma membrane
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Molecular Function:
chloride channel activity; intracellular calcium activated chloride channel activity; phospholipid scramblase activity; protein dimerization activity
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Biological Process:
calcium activated galactosylceramide scrambling; calcium activated phosphatidylcholine scrambling; chloride transmembrane transport; detection of mechanical stimulus; detection of temperature stimulus; establishment of localization in cell; monoatomic ion transmembrane transport
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Disease: Dystonia 24
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Reference #:
Q9BYT9
(UniProtKB)
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Alt. Names/Synonyms: ANO3; anoctamin 3; Anoctamin-3; C11orf25; dystonia 23; DYT23; DYT24; GENX-3947; TMEM16C; Transmembrane protein 16C; transmembrane protein 16C (eight membrane-spanning domains)
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Gene Symbols: ANO3
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Molecular weight:
114,657 Da
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Basal Isoelectric point:
8.87
Predict pI for various phosphorylation states
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