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TRIM34
May function as antiviral protein and may contribute to the defense against retroviral infections. Belongs to the TRIM/RBCC family. Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 11p15.4 |
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Cellular Component:
cytoplasm; cytosol; mitochondrion; nucleoplasm
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Molecular Function:
identical protein binding; protein homodimerization activity; protein kinase binding; ubiquitin protein ligase activity; zinc ion binding
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Biological Process:
defense response to virus; innate immune response; positive regulation of autophagy; positive regulation of DNA-binding transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; protein polyubiquitination; regulation of protein localization; regulation of viral entry into host cell
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Reference #:
Q9BYJ4
(UniProtKB)
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Alt. Names/Synonyms: E3 ubiquitin-protein ligase TRIM34; IFP1; Interferon-responsive finger protein 1; RING finger protein 21; ring finger protein 21, interferon-responsive; RNF21; TRI34; TRIM34; tripartite motif containing 34; tripartite motif-containing 34; Tripartite motif-containing protein 34
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Gene Symbols: TRIM34
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Molecular weight:
56,864 Da
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Basal Isoelectric point:
7.43
Predict pI for various phosphorylation states
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