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PPM1F
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis. Belongs to the PP2C family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 22q11.22 |
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Cellular Component:
cytosol; nucleus; perinuclear region of cytoplasm; protein-containing complex
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Molecular Function:
calmodulin-dependent protein phosphatase activity; metal ion binding; myosin phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
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Biological Process:
cellular response to xenobiotic stimulus; intrinsic apoptotic signaling pathway; negative regulation of cell-cell adhesion mediated by cadherin; negative regulation of DNA-templated transcription; negative regulation of peptidyl-serine phosphorylation; negative regulation of protein kinase activity; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of protein transport; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; positive regulation of cell migration; positive regulation of cell-substrate adhesion; positive regulation of chemotaxis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of epithelial cell migration; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of growth; positive regulation of stress fiber assembly; protein dephosphorylation; regulation of protein localization
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Reference #:
P49593
(UniProtKB)
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Alt. Names/Synonyms: Ca(2+)/calmodulin-dependent protein kinase phosphatase; CaM-kinase phosphatase; CAMKP; CaMKPase; FEM-2; hFem-2; KIAA0015; Partner of PIX 2; POPX2; PP2C phosphatase; PPM1F; Protein fem-2 homolog; Protein phosphatase 1F; protein phosphatase 1F (PP2C domain containing); protein phosphatase, Mg2+/Mn2+ dependent 1F; protein phosphatase, Mg2+/Mn2+ dependent, 1F
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Gene Symbols: PPM1F
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Molecular weight:
49,831 Da
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Basal Isoelectric point:
4.99
Predict pI for various phosphorylation states
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