DUSP14 a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (ERK, JNK, p38). Is a negative regulator of T cell costimulation via CD28. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 11 C|11 51.29 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  dephosphorylation; protein amino acid dephosphorylation
Reference #:  Q9JLY7 (UniProtKB)
Alt. Names/Synonyms: 1110014C10Rik; 2310042C07Rik; D11Ertd395e; dual specificity phosphatase 14; Dual specificity protein phosphatase 14; DUS14; Dusp14; MAP kinase phosphatase 6; MAP kinase phsophatase 6; Mitogen-activated protein kinase phosphatase 6; Mkp-1 like protein tyrosine phosphatase; MKP-6; MKP-L; Mkp6; OTTMUSP00000000916; OTTMUSP00000000917; OTTMUSP00000000919
Gene Symbols: Dusp14
Molecular weight: 22,311 Da
Basal Isoelectric point: 9.48  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene