GSTA1
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid. Belongs to the GST superfamily. Alpha family. Liver. Note: This description may include information from UniProtKB.
|
Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 |
Chromosomal Location of human Ortholog: 6p12.2 |
Cellular Component:
cytosol
|
Molecular Function:
fatty acid binding; glutathione peroxidase activity; glutathione transferase activity; steroid delta-isomerase activity
|
Biological Process:
cellular oxidant detoxification; epithelial cell differentiation; glutathione derivative biosynthetic process; glutathione metabolic process; linoleic acid metabolic process; prostaglandin metabolic process; xenobiotic metabolic process
|
Reference #:
P08263
(UniProtKB)
|
Alt. Names/Synonyms: 13-hydroperoxyoctadecadienoate peroxidase; Androst-5-ene-3,17-dione isomerase; glutathione S-alkyltransferase A1; glutathione S-aryltransferase A1; glutathione S-transferase 2; Glutathione S-transferase A1; Glutathione S-transferase A1, N-terminally processed; glutathione S-transferase alpha 1; glutathione S-transferase Ha subunit 1; GST class-alpha member 1; GST HA subunit 1; GST, class alpha, 1; GST-epsilon; GST2; GSTA1; GSTA1-1; GTH1; MGC131939; S-(hydroxyalkyl)glutathione lyase A1; testicular tissue protein Li 80
|
Gene Symbols: GSTA1
|
Molecular weight:
25,631 Da
|
Basal Isoelectric point:
8.91
Predict pI for various phosphorylation states
|