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DUSP10
Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Detected in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 1q41 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
JUN kinase binding; MAP kinase phosphatase activity; MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase p38 binding; myosin phosphatase activity; phosphatase activity; protein binding; protein tyrosine/threonine phosphatase activity
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Biological Process:
dephosphorylation; negative regulation of cell migration; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelium regeneration; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of JUN kinase activity; negative regulation of oligodendrocyte differentiation; negative regulation of p38MAPK cascade; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of respiratory burst involved in inflammatory response; oligodendrocyte differentiation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of regulatory T cell differentiation; regulation of adaptive immune response; regulation of brown fat cell differentiation; response to lipopolysaccharide; stress-activated MAPK cascade
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Reference #:
Q9Y6W6
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 10; dual specificity phosphatase MKP-5; Dual specificity protein phosphatase 10; DUS10; DUSP10; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; MKP-5; MKP5; serine/threonine specific protein phosphatase
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Gene Symbols: DUSP10
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Molecular weight:
52,642 Da
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Basal Isoelectric point:
7.87
Predict pI for various phosphorylation states
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CST Pathways:
SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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