DUSP10 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of induction by extracellular stimuli. Inactivates MAP kinases of the p38 and JNK subfamily, but not the ERK subfamily. Inhibits myogenesis and regeneration of skeletal muscle. It is evenly distributed in both the cytoplasm and the nucleus. Widely expressed in various tissues and organs, and its expression is elevated by stress stimuli. Inhibits intestinal epithelial cell growth. Mice deficient in expression of DUSP10 contained elevated levels of circulating IL-6 compared to wild type mice, apparently due to hyperphosphorylation of the DUSP10 substrate RAB3IL1. Elevated levels of expression in colorectal cancer patients were associated with improved survival probability. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 1q41
Cellular Component:  cytoplasm; cytosol; Golgi apparatus; nuclear speck; nucleoplasm; nucleus
Molecular Function:  JUN kinase binding; MAP kinase phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase p38 binding; phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; negative regulation of cell migration; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation; negative regulation of epithelium regeneration; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of JUN kinase activity; negative regulation of oligodendrocyte differentiation; negative regulation of p38MAPK cascade; negative regulation of protein kinase activity by regulation of protein phosphorylation; negative regulation of respiratory burst involved in inflammatory response; oligodendrocyte differentiation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of regulatory T cell differentiation; protein dephosphorylation; regulation of adaptive immune response; regulation of brown fat cell differentiation; response to lipopolysaccharide
Reference #:  Q9Y6W6 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 10; dual specificity phosphatase MKP-5; Dual specificity protein phosphatase 10; DUS10; DUSP10; MAP kinase phosphatase 5; Mitogen-activated protein kinase phosphatase 5; MKP-5; MKP5; serine/threonine specific protein phosphatase
Gene Symbols: DUSP10
Molecular weight: 52,642 Da
Basal Isoelectric point: 7.87  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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