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HMHA1
Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Expressed on cells of the hematopoietic lineage. Detected in dendritic cells and epidermal Langerhans cells. Expressed in peripheral blood mononuclear cells, in all leukemia/lymphoma cell lines. Detected also in some solid tumors and tissues such as cancerous and non-cancerous tissue. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell surface; GAP; GAP, Rac/Rho |
| Chromosomal Location of mouse Ortholog: 10|10 C1 |
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Cellular Component:
cell projection; cytoplasm; cytosol; membrane; plasma membrane
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Molecular Function:
GTPase activator activity; metal ion binding
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Biological Process:
activation of GTPase activity; signal transduction
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Reference #:
Q3TBD2
(UniProtKB)
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Alt. Names/Synonyms: 6330406L22Rik; Arhgap45; AW539505; Ha-1; histocompatibility (minor) HA-1; Hmha; Hmha1; KIAA0223; Minor histocompatibility protein HA-1; OTTMUSP00000020659; Rho GTPase activating protein 45; Rho GTPase-activating protein 45
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Gene Symbols: Arhgap45
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Molecular weight:
122,902 Da
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Basal Isoelectric point:
5.66
Predict pI for various phosphorylation states
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