MDS1 A chromosomal aberration involving MDS1 is found in a form of acute myeloid leukemia (AML). Translocation t(3;21) with AML1. 6 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component:  histone deacetylase complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA binding transcription factor activity; metal ion binding; nucleic acid binding; protein binding; protein homodimerization activity; sequence-specific DNA binding
Biological Process:  anatomical structure development; apoptosis; cell differentiation; embryonic forelimb morphogenesis; embryonic hindlimb morphogenesis; forebrain development; hematopoietic stem cell proliferation; in utero embryonic development; inflammatory response; maintenance of cell number; multicellular organism development; negative regulation of JNK cascade; negative regulation of programmed cell death; negative regulation of transcription, DNA-dependent; neutrophil homeostasis; pericardium development; positive regulation of brown fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; post-embryonic development; regulation of cell cycle; regulation of cell proliferation; regulation of transcription, DNA-templated; renal system development; response to bacterium; transcription, DNA-dependent
Reference #:  P14404-3 (UniProtKB)
Alt. Names/Synonyms: Mds1; MDS1 and EVI1 complex locus protein MDS1; Mecom; Myelodysplasia syndrome 1 protein homolog
Gene Symbols: Mecom
Molecular weight: 14,329 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene