GLUT1 Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  apical plasma membrane; basolateral plasma membrane; caveola; cortical actin cytoskeleton; cytosol; female germ cell nucleus; female pronucleus; Golgi membrane; intercalated disc; melanosome; membrane; midbody; photoreceptor inner segment; plasma membrane; presynapse; sarcolemma; Z disc
Molecular Function:  D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity; identical protein binding; kinase binding; long-chain fatty acid transporter activity; protein binding; protein self-association; xenobiotic transmembrane transporter activity
Biological Process:  cellular hyperosmotic response; cellular response to glucose starvation; cellular response to mechanical stimulus; central nervous system development; cerebral cortex development; dehydroascorbic acid transport; female pregnancy; glucose import; glucose import across plasma membrane; glucose transmembrane transport; L-ascorbic acid metabolic process; long-chain fatty acid import across plasma membrane; monosaccharide transmembrane transport; photoreceptor cell maintenance; protein-containing complex assembly; response to hypoxia; response to insulin; response to Thyroglobulin triiodothyronine; transport across blood-brain barrier; xenobiotic transport
Disease: Dystonia 9; Epilepsy, Idiopathic Generalized, Susceptibility To, 12; Glut1 Deficiency Syndrome 1; Glut1 Deficiency Syndrome 2; Stomatin-deficient Cryohydrocytosis With Neurologic Defects
Reference #:  P11166 (UniProtKB)
Alt. Names/Synonyms: choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity); CSE; DYT17; DYT18; DYT9; EIG12; Glucose transporter type 1, erythrocyte/brain; GLUT; GLUT-1; GLUT1; GLUT1DS; GTR1; HepG2 glucose transporter; HTLVR; human T-cell leukemia virus (I and II) receptor; MGC141895; MGC141896; PED; receptor for HTLV-1 and HTLV-2; SDCHCN; SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1; solute carrier family 2 member 1; Solute carrier family 2, facilitated glucose transporter member 1
Gene Symbols: SLC2A1
Molecular weight: 54,084 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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GLUT1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene