DUSP7 Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Strongly expressed in liver (PubMed:8670865). Expressed at significantly higher levels in malignant hematopoietic cells than in corresponding non-malignant cells (PubMed:14576828). 2 human isoforms generated by alternative promoter usage have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 3p21.2
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  MAP kinase tyrosine/serine/threonine phosphatase activity; protein binding; protein tyrosine phosphatase activity
Biological Process:  activation of MAPK activity; inactivation of MAPK activity; MAPK cascade; negative regulation of MAP kinase activity; peptidyl-tyrosine dephosphorylation
Reference #:  Q16829 (UniProtKB)
Alt. Names/Synonyms: DKFZp586F2224; dual specificity phosphatase 7; Dual specificity protein phosphatase 7; Dual specificity protein phosphatase PYST2; dual-specificity phosphatase-7; DUS7; DUSP7; MKPX; PYST2
Gene Symbols: DUSP7
Molecular weight: 44,957 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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DUSP7

Protein Structure Not Found.


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