DUSP6 Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 10|10 D1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; negative regulation of ERK1 and ERK2 cascade; negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of apoptotic process; positive regulation of cell death; protein dephosphorylation; regulation of heart growth
Reference #:  Q9DBB1 (UniProtKB)
Alt. Names/Synonyms: 1300019I03Rik; dual specificity phosphatase 6; Dual specificity protein phosphatase 6; DUS6; Dusp6; MAP kinase phosphatase 3; MGC98540; Mitogen-activated protein kinase phosphatase 3; MKP; MKP-; MKP-3; Mkp3; PYS; PYST1
Gene Symbols: Dusp6
Molecular weight: 42,408 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene