DUSP6 a non-receptor, dual-specificity phosphoprotein phosphatase. Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This protein inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 10|10 D1
Cellular Component:  cytoplasm; cytosol
Molecular Function:  hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; negative regulation of ERK1 and ERK2 cascade; negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of apoptotic process; positive regulation of cell death; protein dephosphorylation; regulation of heart growth
Reference #:  Q9DBB1 (UniProtKB)
Alt. Names/Synonyms: 1300019I03Rik; dual specificity phosphatase 6; Dual specificity protein phosphatase 6; DUS6; Dusp6; MAP kinase phosphatase 3; MGC98540; Mitogen-activated protein kinase phosphatase 3; MKP-3; Mkp3; PYST1
Gene Symbols: Dusp6
Molecular weight: 42,408 Da
Basal Isoelectric point: 4.75  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene