WDR43
Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Belongs to the UTP5 family. Note: This description may include information from UniProtKB.
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Protein type: Nucleolus; Unknown function |
Chromosomal Location of human Ortholog: 2p23.2 |
Cellular Component:
chromatin; fibrillar center; nucleolus; nucleoplasm; small-subunit processome
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Molecular Function:
protein binding; RNA polymerase II complex binding; transcription elongation factor activity
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Biological Process:
DNA-templated transcription; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; regulation of stem cell population maintenance; regulation of transcription elongation by RNA polymerase II; ribosomal small subunit biogenesis
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Reference #:
Q15061
(UniProtKB)
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Alt. Names/Synonyms: KIAA0007; NET12; U3 small nucleolar RNA-associated protein 5 homolog; UTP5; UTP5, small subunit (SSU) processome component, homolog; WD repeat domain 43; WD repeat-containing protein 43; WDR43
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Gene Symbols: WDR43
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Molecular weight:
74,891 Da
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Basal Isoelectric point:
5.37
Predict pI for various phosphorylation states
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