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DUSP6
Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 12q21.33 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm
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Molecular Function:
MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
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Biological Process:
cell differentiation; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAPK cascade; negative regulation of protein phosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of apoptotic process; regulation of heart growth; response to growth factor; response to nitrosative stress; response to organic cyclic compound; response to xenobiotic stimulus
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Disease: Hypogonadotropic Hypogonadism 19 With Or Without Anosmia; Hypogonadotropic Hypogonadism 7 With Or Without Anosmia
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Reference #:
Q16828
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 6; Dual specificity protein phosphatase 6; Dual specificity protein phosphatase PYST1; DUS6; DUSP6; HH19; MAP kinase phosphatase 3; Mitogen-activated protein kinase phosphatase 3; MKP-3; MKP3; PYST1; serine/threonine specific protein phosphatase
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Gene Symbols: DUSP6
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Molecular weight:
42,320 Da
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Basal Isoelectric point:
4.75
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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