DUSP5
Dual specificity protein phosphatase; active with phosphotyrosine, phosphoserine and phosphothreonine residues. The highest relative activity is toward ERK1. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Note: This description may include information from UniProtKB.
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Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
Chromosomal Location of human Ortholog: 10q25.2 |
Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; myosin phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
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Biological Process:
dephosphorylation; endoderm formation; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of MAPK cascade; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
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Reference #:
Q16690
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 5; Dual specificity protein phosphatase 5; Dual specificity protein phosphatase hVH3; DUS5; DUSP; DUSP5; HVH3; serine/threonine specific protein phosphatase; VH1-like phosphatase 3; VH3
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Gene Symbols: DUSP5
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Molecular weight:
42,047 Da
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Basal Isoelectric point:
8.69
Predict pI for various phosphorylation states
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