DUSP4 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP4 inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Induced by hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) in human endothelial cells. Two alternatively spliced isoforms have been described. In addition, multiple polyadenylation sites have been reported. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 16q12.2
Cellular Component:  cytoplasm; nucleoplasm; nucleus
Molecular Function:  MAP kinase serine/threonine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; negative regulation of ERK1 and ERK2 cascade; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q62767 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 4; Dual specificity protein phosphatase 4; DUS4; Dusp4; MAP kinase phosphatase 2; Mitogen-activated protein kinase phosphatase 2; MKP-2; Mkp2
Gene Symbols: Dusp4
Molecular weight: 43,187 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein