SNAP-91 Adaptins are components of the adapter complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. Binding of AP180 to clathrin triskelia induces their assembly into 60-70 nm coats. Belongs to the PICALM/SNAP91 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 8q31
Cellular Component:  axon terminus; clathrin-coated pit; clathrin-coated vesicle; cytoplasm; cytosol; extrinsic component of endosome membrane; extrinsic component of presynaptic endocytic zone membrane; neuron projection; neuronal cell body; parallel fiber to Purkinje cell synapse; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone membrane; presynaptic endocytic zone; presynaptic endosome; presynaptic membrane; Schaffer collateral - CA1 synapse; synaptic vesicle
Molecular Function:  1-phosphatidylinositol binding; clathrin adaptor activity; clathrin binding; clathrin heavy chain binding; inositol hexakisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phospholipase binding; protein binding; protein kinase binding; SH2 domain binding; SNARE binding
Biological Process:  axonogenesis; chemical synaptic transmission; clathrin coat assembly; clathrin-dependent endocytosis; endocytosis; establishment or maintenance of cell polarity; membrane depolarization; negative regulation of phospholipase C activity; negative regulation of phospholipase D activity; neuron development; neurotransmitter secretion; positive regulation of axonogenesis; positive regulation of clathrin coat assembly; positive regulation of synaptic vesicle clustering; positive regulation of synaptic vesicle endocytosis; protein transport; regulation of clathrin-dependent endocytosis; regulation of endocytosis; regulation of protein transport; regulation of synaptic vesicle endocytosis; regulation of terminal button organization; synaptic vesicle budding from presynaptic endocytic zone membrane; synaptic vesicle endocytosis; vesicle budding from membrane
Reference #:  Q05140 (UniProtKB)
Alt. Names/Synonyms: 91 kDa synaptosomal-associated protein; Ap180; assembly protein 180 (AP180); Clathrin coat assembly protein AP180; Clathrin coat-associated protein AP180; SNAP-91; Snap91; synaptosomal-associated protein 91; synaptosomal-associated protein 91 kDa; synaptosomal-associated protein, 91 kDa; synaptosomal-associated protein, 91kDa homolog
Gene Symbols: Snap91
Molecular weight: 93,519 Da
Basal Isoelectric point: 4.76  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene