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DUSP2
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Expressed in hematopoietic tissues. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of mouse Ortholog: 2|2 F1 |
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Cellular Component:
cytoplasm; nuclear membrane; nucleoplasm; nucleus
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Molecular Function:
hydrolase activity; MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
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Biological Process:
dephosphorylation; endoderm formation; negative regulation of MAPK cascade; protein dephosphorylation
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Reference #:
Q05922
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; DUS2; Dusp2; OTTMUSP00000017127; Pac-1; Pac1
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Gene Symbols: Dusp2
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Molecular weight:
34,576 Da
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Basal Isoelectric point:
6.5
Predict pI for various phosphorylation states
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