DUSP2 Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Expressed in hematopoietic tissues. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 2|2 F1
Cellular Component:  cytoplasm; nuclear membrane; nucleus
Molecular Function:  hydrolase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; phosphatase activity; phosphoprotein phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
Biological Process:  dephosphorylation; inactivation of MAPK activity; protein dephosphorylation
Reference #:  Q05922 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; DUS2; Dusp2; OTTMUSP00000017127; Pac-1; Pac1
Gene Symbols: Dusp2
Molecular weight: 34,576 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
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DUSP2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene