NOP14
Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm. Belongs to the NOP14 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Nucleolus |
Chromosomal Location of human Ortholog: 4p16.3 |
Cellular Component:
90S preribosome; Noc4p-Nop14p complex; nucleolus; nucleoplasm; small-subunit processome
|
Molecular Function:
enzyme binding; snoRNA binding
|
Biological Process:
endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of SSU-rRNA; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal small subunit biogenesis; rRNA processing
|
Reference #:
P78316
(UniProtKB)
|
Alt. Names/Synonyms: C4orf9; NOL14; NOP14; NOP14 homolog; NOP14 nucleolar protein; NOP14 nucleolar protein homolog; NOP14 nucleolar protein homolog (yeast); Nucleolar complex protein 14; Nucleolar protein 14; nucleolar protein 14 homolog; probable nucleolar complex protein 14; RES4-25; RES425; UTP2
|
Gene Symbols: NOP14
|
Molecular weight:
97,668 Da
|
Basal Isoelectric point:
7.33
Predict pI for various phosphorylation states
|