DUSP2 Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Expressed in hematopoietic tissues. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of human Ortholog: 2q11.2
Cellular Component:  cytoplasm; nuclear membrane; nucleoplasm; nucleus
Molecular Function:  MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; myosin phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  endoderm formation; negative regulation of MAPK cascade; protein dephosphorylation
Reference #:  Q05923 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; DUS2; DUSP2; PAC-1; PAC1; serine/threonine specific protein phosphatase
Gene Symbols: DUSP2
Molecular weight: 34,400 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein