DUSP2 a non-receptor, dual-specificity phosphoprotein phosphatase (DUSP). Different members of the DUSP family show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. DUSP2 is induced by mitogens, inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. Contains 1 rhodanese domain. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component:  nuclear membrane; nucleus
Molecular Function:  mitogen-activated protein kinase binding; protein binding; protein tyrosine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q05923 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC-1; dual-specificity phosphatase 2; DUS2; DUSP2; PAC-1; PAC1; serine/threonine specific protein phosphatase
Gene Symbols: DUSP2
Molecular weight: 34,400 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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