AATF May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family. Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 17q12
Cellular Component:  cytoplasm; Golgi apparatus; nucleus
Molecular Function:  leucine zipper domain binding; protein binding; protein kinase binding; tau protein binding
Biological Process:  cell adhesion; cellular response to DNA damage stimulus; embryonic cleavage; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptotic process; negative regulation of reactive oxygen species metabolic process; negative regulation of superoxide anion generation; positive regulation of transcription by RNA polymerase II; regulation of mitotic cell cycle; ribosome biogenesis
Reference #:  Q9NY61 (UniProtKB)
Alt. Names/Synonyms: AATF; apoptosis antagonizing transcription factor; Apoptosis-antagonizing transcription factor; BFR2; CHE-1; CHE1; DED; Protein AATF; Rb-binding protein Che-1
Gene Symbols: AATF
Molecular weight: 63,133 Da
Basal Isoelectric point: 4.83  Predict pI for various phosphorylation states
Select Structure to View Below

AATF

Protein Structure Not Found.

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