SCOTIN
Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. Belongs to the shisa family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 9|9 F2 |
Cellular Component:
endoplasmic reticulum; membrane; nuclear envelope; nucleus
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Molecular Function:
WW domain binding
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Biological Process:
apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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Reference #:
Q9D7I0
(UniProtKB)
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Alt. Names/Synonyms: 2310008D10Rik; 6430628I05Rik; mShisa5; Protein shisa-5; Scotin; shisa family member 5; shisa homolog 5; shisa homolog 5 (Xenopus laevis); Shisa5; SHSA5
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Gene Symbols: Shisa5
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Molecular weight:
25,517 Da
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Basal Isoelectric point:
5.06
Predict pI for various phosphorylation states
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