DUSP1 Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of human Ortholog: 5q35.1
Cellular Component:  cytoplasm; nucleus
Molecular Function:  growth factor binding; MAP kinase tyrosine/serine/threonine phosphatase activity; mitogen-activated protein kinase binding; protein binding; protein serine/threonine phosphatase activity; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine/threonine phosphatase activity
Biological Process:  cellular response to chemokine; cellular response to hormone stimulus; inactivation of MAPK activity; intracellular signal transduction; mitotic cell cycle arrest; negative regulation of apoptotic process; negative regulation of cell adhesion; negative regulation of cell proliferation; negative regulation of DNA biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of meiotic cell cycle; negative regulation of monocyte chemotaxis; negative regulation of p38MAPK cascade; peptidyl-serine dephosphorylation; peptidyl-threonine dephosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of apoptotic process; regulation of mitotic cell cycle spindle assembly checkpoint; response to calcium ion; response to cAMP; response to estradiol; response to glucocorticoid; response to hydrogen peroxide; response to light stimulus; response to retinoic acid; response to testosterone
Reference #:  P28562 (UniProtKB)
Alt. Names/Synonyms: CL 100; CL100; dual specificity phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUS1; DUSP1; HVH1; MAP kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; Protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase; VH1
Gene Symbols: DUSP1
Molecular weight: 39,298 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene