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DRD5
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Neuron-specific, localized primarily within limbic regions of the brain. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 4p16.1 |
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Cellular Component:
brush border membrane; ciliary membrane; cilium; non-motile cilium; plasma membrane; synapse
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Molecular Function:
dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gs; G protein-coupled receptor activity; protein binding
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; associative learning; cellular calcium ion homeostasis; cellular response to catecholamine stimulus; chemical synaptic transmission; dopamine receptor signaling pathway; long-term synaptic depression; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of adenylate cyclase activity; reactive oxygen species metabolic process; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission, dopaminergic; transmission of nerve impulse; wound healing
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Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
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Reference #:
P21918
(UniProtKB)
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Alt. Names/Synonyms: D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; DBDR; Dopamine D5 receptor; dopamine receptor D1B; dopamine receptor D5; DRD1B; DRD1L2; DRD5
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Gene Symbols: DRD5
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Molecular weight:
52,951 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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