DRD5 Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Neuron-specific, localized primarily within limbic regions of the brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 4p16.1
Cellular Component:  brush border membrane; ciliary membrane; cilium; non-motile cilium; plasma membrane; synapse
Molecular Function:  dopamine binding; dopamine neurotransmitter receptor activity; dopamine neurotransmitter receptor activity, coupled via Gs; G protein-coupled receptor activity; protein binding
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; associative learning; cellular calcium ion homeostasis; cellular response to catecholamine stimulus; chemical synaptic transmission; dopamine receptor signaling pathway; long-term synaptic depression; negative regulation of blood pressure; negative regulation of NAD(P)H oxidase activity; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; phospholipase C-activating dopamine receptor signaling pathway; positive regulation of adenylate cyclase activity; reactive oxygen species metabolic process; regulation of female receptivity; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to cocaine; sensitization; synaptic transmission, dopaminergic; transmission of nerve impulse; wound healing
Disease: Attention Deficit-hyperactivity Disorder; Blepharospasm, Benign Essential
Reference #:  P21918 (UniProtKB)
Alt. Names/Synonyms: D(1B) dopamine receptor; D(5) dopamine receptor; D1beta dopamine receptor; DBDR; Dopamine D5 receptor; dopamine receptor D1B; dopamine receptor D5; DRD1B; DRD1L2; DRD5
Gene Symbols: DRD5
Molecular weight: 52,951 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein