C5aR Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  apical part of cell; basolateral plasma membrane; cell surface; cytoplasmic vesicle; integral component of membrane; plasma membrane
Molecular Function:  complement component C5a binding; complement component C5a receptor activity; G protein-coupled receptor activity
Biological Process:  animal organ regeneration; apoptotic process; cell proliferation in hindbrain; chemotaxis; cognition; complement component C5a signaling pathway; complement receptor mediated signaling pathway; defense response to Gram-positive bacterium; inflammatory response; mRNA transcription by RNA polymerase II; negative regulation of neuron apoptotic process; neutrophil chemotaxis; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of vascular endothelial growth factor production; presynapse organization; regulation of amyloid-beta clearance; regulation of astrocyte activation; regulation of microglial cell activation; regulation of tau-protein kinase activity; response to lipopolysaccharide; response to peptidoglycan
Reference #:  P97520 (UniProtKB)
Alt. Names/Synonyms: C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a-R; C5aR; C5ar1; C5r1; complement C5a receptor; complement component 5, receptor 1; complement component 5a receptor 1
Gene Symbols: C5ar1
Molecular weight: 39,417 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
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C5aR

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept