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BCCIP
During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ). Belongs to the BCP1 family. Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 7|7 F3 |
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Cellular Component:
centriole; centrosome; cytoplasm; cytoskeleton; cytosol; mitotic spindle pole; nuclear cyclin-dependent protein kinase holoenzyme complex; nucleoplasm; nucleus
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Molecular Function:
kinase regulator activity; tubulin binding
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Biological Process:
cell cycle; DNA damage response; DNA repair; establishment of mitotic spindle orientation; microtubule anchoring; microtubule cytoskeleton organization; mitotic spindle assembly; mitotic spindle organization; neuroendocrine cell differentiation; regulation of cyclin-dependent protein serine/threonine kinase activity
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Reference #:
Q9CWI3
(UniProtKB)
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Alt. Names/Synonyms: 1110013J05Rik; Bccip; BRCA2 and CDKN1A interacting protein; BRCA2 and CDKN1A-interacting protein; OTTMUSP00000025772; TOK-; TOK-1
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Gene Symbols: Bccip
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Molecular weight:
35,942 Da
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Basal Isoelectric point:
4.36
Predict pI for various phosphorylation states
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