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CMKLR2
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation. Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. (Microbial infection) Coreceptor for HIV-1. Belongs to the G-protein coupled receptor 1 family. Expressed in hippocampus. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 1|1 C2 |
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Cellular Component:
intracellular membrane-bounded organelle; membrane; neuron projection; nucleoplasm; plasma membrane
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Molecular Function:
adipokinetic hormone binding; adipokinetic hormone receptor activity; G protein-coupled receptor activity; neuropeptide binding
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Biological Process:
G protein-coupled receptor signaling pathway; glucose homeostasis; neuropeptide signaling pathway; signal transduction
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Reference #:
Q8K087
(UniProtKB)
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Alt. Names/Synonyms: chemerin chemokine-like receptor 2; Chemerin-like receptor 2; Cmklr2; g protein-coupled receptor 1; G-protein coupled receptor 1; gpr1; mgc41704; probable G-protein coupled receptor 1
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Gene Symbols: Cmklr2
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Molecular weight:
40,951 Da
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Basal Isoelectric point:
8.59
Predict pI for various phosphorylation states
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