MRGPRX1 Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily. Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11p15.1|11
Cellular Component:  cell surface; integral component of membrane; plasma membrane
Molecular Function:  transmembrane signaling receptor activity
Biological Process:  acute-phase response; cell surface receptor signaling pathway; response to chloroquine; signal transduction
Reference #:  Q96LB2 (UniProtKB)
Alt. Names/Synonyms: g protein-coupled receptor mrgx1; g protein-coupled receptor snsr3; GPCR; MAS related GPR family member X1; Mas-related G protein-coupled receptor G2; Mas-related G-protein coupled receptor member X1; mas-related gpr, member x1; MGRG2; mrgprx1; mrgx1; Sensory neuron-specific G-protein coupled receptor 3/4; SNSR3; snsr4
Gene Symbols: MRGPRX1
Molecular weight: 36,250 Da
Basal Isoelectric point: 7.5  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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