OXTR Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 3p25.3
Cellular Component:  adherens junction; apical plasma membrane; microvillus; plasma membrane
Molecular Function:  G protein-coupled receptor activity; oxytocin receptor activity; peptide binding; peptide hormone binding; vasopressin receptor activity
Biological Process:  cell surface receptor signaling pathway; digestive tract development; eating behavior; ERK1 and ERK2 cascade; estrous cycle; female pregnancy; G protein-coupled receptor signaling pathway; heart development; lactation; maternal behavior; maternal process involved in parturition; memory; muscle contraction; negative regulation of gastric acid secretion; positive regulation of blood pressure; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of norepinephrine secretion; positive regulation of penile erection; positive regulation of synapse assembly; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of uterine smooth muscle contraction; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to anoxia; response to cocaine; response to cytokine; response to estradiol; response to peptide hormone; response to progesterone; response to xenobiotic stimulus; sleep; social behavior; sperm ejaculation; suckling behavior; telencephalon development
Reference #:  P30559 (UniProtKB)
Alt. Names/Synonyms: ot-r; oxtr; oxyr; Oxytocin receptor
Gene Symbols: OXTR
Molecular weight: 42,772 Da
Basal Isoelectric point: 9.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein