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OXTR
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 3p25.3 |
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Cellular Component:
adherens junction; apical plasma membrane; microvillus; plasma membrane
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Molecular Function:
G protein-coupled receptor activity; oxytocin receptor activity; peptide binding; peptide hormone binding; vasopressin receptor activity
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Biological Process:
cell surface receptor signaling pathway; digestive tract development; eating behavior; ERK1 and ERK2 cascade; estrous cycle; female pregnancy; G protein-coupled receptor signaling pathway; heart development; lactation; maternal behavior; maternal process involved in parturition; memory; muscle contraction; negative regulation of gastric acid secretion; positive regulation of blood pressure; positive regulation of cold-induced thermogenesis; positive regulation of cytosolic calcium ion concentration; positive regulation of norepinephrine secretion; positive regulation of penile erection; positive regulation of synapse assembly; positive regulation of synaptic transmission, GABAergic; positive regulation of synaptic transmission, glutamatergic; positive regulation of uterine smooth muscle contraction; positive regulation of vasoconstriction; regulation of systemic arterial blood pressure by vasopressin; response to amphetamine; response to anoxia; response to cocaine; response to cytokine; response to estradiol; response to peptide hormone; response to progesterone; response to xenobiotic stimulus; sleep; social behavior; sperm ejaculation; suckling behavior; telencephalon development
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Reference #:
P30559
(UniProtKB)
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Alt. Names/Synonyms: ot-r; oxtr; oxyr; Oxytocin receptor
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Gene Symbols: OXTR
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Molecular weight:
42,772 Da
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Basal Isoelectric point:
9.63
Predict pI for various phosphorylation states
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