H2AC8 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 6p22.2
Cellular Component:  CENP-A containing nucleosome; nucleosome; nucleus
Molecular Function:  DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin
Biological Process:  negative regulation of cell population proliferation; protein localization to CENP-A containing chromatin
Reference #:  P04908 (UniProtKB)
Alt. Names/Synonyms: H2A clustered histone 8; H2A histone family, member A; H2A.1; H2A.2; H2A/a; H2A1B; H2AC4; H2AC8; h2afa; h2afm; HIST1H2AB; hist1h2ae; histone 1, H2ae; histone cluster 1 H2A family member e; histone cluster 1, H2ae; Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; histone H2AE
Gene Symbols: H2AC4; H2AC8
Molecular weight: 14,004 Da
Basal Isoelectric point: 11.05  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene