H2AC8
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of human Ortholog: 6p22.2 |
Cellular Component:
CENP-A containing nucleosome; nucleosome; nucleus
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Molecular Function:
DNA binding; protein binding; protein heterodimerization activity; structural constituent of chromatin
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Biological Process:
negative regulation of cell population proliferation; protein localization to CENP-A containing chromatin
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Reference #:
P04908
(UniProtKB)
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Alt. Names/Synonyms: H2A clustered histone 8; H2A histone family, member A; H2A.1; H2A.2; H2A/a; H2A1B; H2AC4; H2AC8; h2afa; h2afm; HIST1H2AB; hist1h2ae; histone 1, H2ae; histone cluster 1 H2A family member e; histone cluster 1, H2ae; Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m; histone H2AE
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Gene Symbols: H2AC8
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Molecular weight:
14,004 Da
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Basal Isoelectric point:
11.05
Predict pI for various phosphorylation states
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