4E-BP1 Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Belongs to the eIF4E-binding protein family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Cellular Component:  cytoplasm
Molecular Function:  eukaryotic initiation factor 4E binding
Biological Process:  antibacterial humoral response; cellular response to insulin stimulus; determination of adult lifespan; immune response; myoblast fusion; negative regulation of cell size; negative regulation of translational initiation; regulation of cell growth; regulation of mitochondrial translation; regulation of terminal button organization; response to bacterium; response to oxidative stress; response to starvation; somatic muscle development; triglyceride metabolic process; vascular endothelial growth factor receptor signaling pathway
Reference #:  NP_477295 (RefSeq)
Alt. Names/Synonyms: 4E-BP1; Thor
Gene Symbols: Thor
Molecular weight: 12,876 Da
Basal Isoelectric point: 9.69  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Angiogenesis  |  Insulin Receptor Signaling  |  mTOR Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
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4E-BP1

Protein Structure Not Found.


Cross-references to other databases:  Entrez-Gene  |  GenPept