LSS
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. Belongs to the terpene cyclase/mutase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 5.4.99.7; Isomerase; Lipid Metabolism - steroid biosynthesis |
Chromosomal Location of human Ortholog: 21q22.3 |
Cellular Component:
endoplasmic reticulum membrane; lipid droplet
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Molecular Function:
lanosterol synthase activity; protein binding
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Biological Process:
cholesterol biosynthetic process; regulation of protein stability; steroid biosynthetic process; triterpenoid biosynthetic process
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Disease: Alopecia-mental Retardation Syndrome 4; Cataract 44; Hypotrichosis 14
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Reference #:
P48449
(UniProtKB)
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Alt. Names/Synonyms: 2,3-epoxysqualene--lanosterol cyclase; 2,3-epoxysqualene-lanosterol cyclase; APMR4; CTRCT44; epididymis secretory sperm binding protein; ERG7; FLJ25486; FLJ35015; FLJ39450; FLJ46393; hOSC; HYPT14; Lanosterol synthase; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); LSS; OSC; Oxidosqualene--lanosterol cyclase
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Gene Symbols: LSS
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Molecular weight:
83,309 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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