NFM a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 15p12
Cellular Component:  axon; cytoskeleton; intermediate filament; intermediate filament cytoskeleton; neurofibrillary tangle; neurofilament; neuromuscular junction; neuron projection; perikaryon; postsynaptic density; postsynaptic intermediate filament cytoskeleton; presynaptic intermediate filament cytoskeleton
Molecular Function:  protein heterodimerization activity; signaling receptor binding; structural molecule activity; toxic substance binding
Biological Process:  axo-dendritic transport; axon development; axon regeneration; cellular response to estradiol stimulus; cellular response to oxidative stress; cerebral cortex development; hippocampus development; intermediate filament bundle assembly; intermediate filament cytoskeleton organization; intermediate filament polymerization or depolymerization; microtubule cytoskeleton organization; neurofilament bundle assembly; neurofilament cytoskeleton organization; regulation of axon diameter; response to acrylamide; spinal cord development
Reference #:  P12839 (UniProtKB)
Alt. Names/Synonyms: 160 kDa neurofilament protein; Nef3; Nefm; Neurofilament 3; neurofilament 3, medium; Neurofilament medium polypeptide; Neurofilament protein, middle polypeptide; Neurofilament triplet M protein; neurofilament, medium polypeptide; NF-M; Nfm
Gene Symbols: Nefm
Molecular weight: 95,791 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene