PIP4K2B Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Highly expressed in brain, heart, pancreas, skeletal muscle and kidney. Detected at lower levels in placenta, lung and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11 D|11 61.07 cM
Cellular Component:  autophagosome; cytoplasm; endoplasmic reticulum; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; ATP binding; kinase activity; nucleotide binding; phosphatidylinositol phosphate kinase activity; protein binding; protein homodimerization activity; transferase activity
Biological Process:  phosphatidylinositol metabolic process; phosphorylation; positive regulation of autophagosome assembly; regulation of autophagy
Reference #:  Q80XI4 (UniProtKB)
Alt. Names/Synonyms: 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; AI848124; c11; Diphosphoinositide kinase 2-beta; OTTMUSP00000002594; Phosphatidylinositol 5-phosphate 4-kinase type II beta; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta; Phosphatidylinositol-5-phosphate 4-kinase type II beta; Phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol-5-phosphate 4-kinase, type II, beta; PI(5)P 4-kinase type II beta; PI42B; PI5P4K; PI5P4Kbeta; Pip4k2b; PIP4KII-beta; Pip5; Pip5k2b; PtdIns(5)P-4-kinase isoform 2-beta
Gene Symbols: Pip4k2b
Molecular weight: 47,319 Da
Basal Isoelectric point: 6.9  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PIP4K2B

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene