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LC3A
Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Belongs to the ATG8 family. Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle |
| Chromosomal Location of mouse Ortholog: 2|2 H1 |
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Cellular Component:
autolysosome; autophagosome; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; late endosome; membrane; microtubule; microtubule cytoskeleton; organelle membrane; synapse
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Molecular Function:
microtubule binding; phosphatidylethanolamine binding; phospholipid binding; protein binding; ubiquitin protein ligase binding
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Biological Process:
autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy
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Reference #:
Q91VR7
(UniProtKB)
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Alt. Names/Synonyms: 1010001H21Rik; 4922501H04Rik; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; Map1lc3a; Microtubule-associated protein 1 light chain 3 alpha; Microtubule-associated proteins 1A/1B light chain 3A; MLP3A; OTTMUSP00000017090
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Gene Symbols: Map1lc3a
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Molecular weight:
14,272 Da
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Basal Isoelectric point:
8.73
Predict pI for various phosphorylation states
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CST Pathways:
Autophagy Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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