LC3A Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Belongs to the ATG8 family. Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle
Chromosomal Location of mouse Ortholog: 2|2 H1
Cellular Component:  autolysosome; autophagosome; autophagosome membrane; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; late endosome; membrane; microtubule; microtubule cytoskeleton; organelle membrane; synapse
Molecular Function:  microtubule binding; phosphatidylethanolamine binding; phospholipid binding; protein binding; ubiquitin protein ligase binding
Biological Process:  autophagosome assembly; autophagosome maturation; autophagy; autophagy of mitochondrion; cellular response to nitrogen starvation; cellular response to starvation; macroautophagy
Reference #:  Q91VR7 (UniProtKB)
Alt. Names/Synonyms: 1010001H21Rik; 4922501H04Rik; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; LC3; LC3A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; Map1lc3a; Microtubule-associated protein 1 light chain 3 alpha; Microtubule-associated proteins 1A/1B light chain 3A; MLP3A; OTTMUSP00000017090
Gene Symbols: Map1lc3a
Molecular weight: 14,272 Da
Basal Isoelectric point: 8.73  Predict pI for various phosphorylation states
CST Pathways:  Autophagy Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein