|
INA
Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family. Found predominantly in adult CNS. Note: This description may include information from UniProtKB.
|
| Protein type: Cytoskeletal |
| Chromosomal Location of human Ortholog: 10q24.33 |
|
Cellular Component:
cytoplasm; cytoplasmic ribonucleoprotein granule; intermediate filament; neurofilament; postsynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
|
|
Molecular Function:
protein binding; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
|
|
Biological Process:
cell differentiation; cellular response to leukemia inhibitory factor; intermediate filament organization; neurofilament cytoskeleton organization; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission
|
|
Reference #:
Q16352
(UniProtKB)
|
|
Alt. Names/Synonyms: 66 kDa neurofilament protein; AINX; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; INA; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; MGC12702; NEF5; Neurofilament 5; neurofilament 5 (66kD); Neurofilament-66; neurofilament-66, tax-binding protein; NF-66; TXBP-1
|
|
Gene Symbols: INA
|
|
Molecular weight:
55,391 Da
|
|
Basal Isoelectric point:
5.34
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
