INA Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family. Found predominantly in adult CNS. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 10q24.33
Cellular Component:  cytoplasm; cytoplasmic ribonucleoprotein granule; intermediate filament; neurofilament; postsynaptic intermediate filament cytoskeleton; Schaffer collateral - CA1 synapse
Molecular Function:  protein binding; structural constituent of cytoskeleton; structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process:  cell differentiation; cellular response to leukemia inhibitory factor; intermediate filament organization; neurofilament cytoskeleton organization; postsynaptic intermediate filament cytoskeleton organization; postsynaptic modulation of chemical synaptic transmission
Reference #:  Q16352 (UniProtKB)
Alt. Names/Synonyms: 66 kDa neurofilament protein; AINX; Alpha-internexin; Alpha-Inx; FLJ18662; FLJ57501; INA; internexin neuronal intermediate filament protein alpha; internexin neuronal intermediate filament protein, alpha; MGC12702; NEF5; Neurofilament 5; neurofilament 5 (66kD); Neurofilament-66; neurofilament-66, tax-binding protein; NF-66; TXBP-1
Gene Symbols: INA
Molecular weight: 55,391 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene