APRT Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.2.7; Nucleotide Metabolism - purine; Transferase
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  cytoplasm; cytosol; extracellular region; nucleoplasm; secretory granule lumen
Molecular Function:  AMP binding
Biological Process:  AMP salvage; cellular response to insulin stimulus; grooming behavior; lactation; neutrophil degranulation; purine ribonucleoside salvage; purine-containing compound salvage
Disease: Adenine Phosphoribosyltransferase Deficiency
Reference #:  P07741 (UniProtKB)
Alt. Names/Synonyms: Adenine phosphoribosyltransferase; AMP; AMP diphosphorylase; AMP pyrophosphorylase; APRT; APT; DKFZp686D13177; MGC125856; MGC125857; MGC129961; transphosphoribosidase
Gene Symbols: APRT
Molecular weight: 19,608 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
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APRT

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene